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A patient with previously incidental gallstones who starts high-dose GLP-1 therapy has a substantially elevated risk of developing an acute biliary event

Patients with chronic alcohol intake who need to protect their liver, chronic smokers who would like to quit and so on

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This means that unlike simply being in a calorie deficit where you risk losing muscle, glucagon receptor activation is associated with increased energy expenditure pathways in muscle, and ongoing research is evaluating potential body-composition differences compared with GLP-1only compounds

Organization for Economic Cooperation and Development (OECD)